Ethos PUSH: Finding a Cure for Hemangiosarcoma

The Ethos-PUSH study seeks to deliver a highly advanced program investigating the use of novel drugs for the treatment of hemangiosarcoma (HSA) with the goal of curing this aggressive cancer. Ethos Discovery’s previous work in HSA has taught us that HSA is not a single cancer but is rather at least four different subtypes of cancer, each characterized by a different genomic mutation. Previous studies evaluating drugs for the treatment of HSA have shown variable results, and the discovery of these different subtypes could explain this phenomenon.

This study will ask if drugs specifically matched to these genomic subtypes of patients with HSA can improve their outcomes. Our trial has already demonstrated that a greater number of dogs (40-50%) with a ruptured splenic tumor end up having a benign diagnosis that is cured with surgery alone.