This lecture will provide essential information on negative pressure wound therapy (NPWT) for equine surgeons, concentrating on case selection, wound preparation, and the application of NPWT units. In addition to reviewing NPWT's effects on wounds, we will cover monitoring strategies for patients undergoing NPWT and troubleshooting common issues that may arise during treatment. The lecture will also highlight novel applications of NPWT, demonstrating its versatility in managing complex wounds across various clinical scenarios.